Combined therapies of antithrombotics and antioxidants delay in silico brain tumor progression

Glioblastoma multiforme, the most frequent type of primary brain tumor, is a rapidly evolving and spatially heterogeneous high-grade astrocytoma that presents areas of necrosis, hypercellularity and microvascular hyperplasia. The aberrant vasculature leads to hypoxic areas and results in an increase of the oxidative stress selecting for more invasive tumor cell phenotypes. In our study we assay in silico different therapeutic approaches which combine antithrombotics, antioxidants and standard radiotherapy. To do so, we have developed a biocomputational model of glioblastoma multiforme that incorporates the spatio-temporal interplay among two glioma cell phenotypes corresponding to oxygenated and hypoxic cells, a necrotic core and the local vasculature whose response evolves with tumor progression. Our numerical simulations predict that suitable combinations of antithrombotics and antioxidants may diminish, in a synergetic way, oxidative stress and the subsequent hypoxic response. This novel therapeutical strategy, with potentially low or no toxicity, might reduce tumor invasion and further sensitize glioblastoma multiforme to conventional radiotherapy or other cytotoxic agents, hopefully increasing median patient overall survival time.Comment: 8 figure

Spatial wave intensity correlations in quasi-one-dimensional wires

Spatial intensity correlations between waves transmitted through random media are analyzed within the framework of the random matrix theory of transport. Assuming that the statistical distribution of transfer matrices is isotropic, we found that the spatial correlation function can be expressed as the sum of three terms, with distinctive spatial dependences. This result coincides with the one obtained in the diffusive regime from perturbative calculations, but holds all the way from quasi-ballistic transport to localization. While correlations are positive in the diffusive regime, we predict a transition to negative correlations as the length of the system decreases.Comment: 10 pages, 3 figures. Submitted to Physical Review Letter

Visual Spike-based Convolution Processing with a Cellular Automata Architecture

this paper presents a first approach for implementations which fuse the Address-Event-Representation (AER) processing with the Cellular Automata using FPGA and AER-tools. This new strategy applies spike-based convolution filters inspired by Cellular Automata for AER vision processing. Spike-based systems are neuro-inspired circuits implementations traditionally used for sensory systems or sensor signal processing. AER is a neuromorphic communication protocol for transferring asynchronous events between VLSI spike-based chips. These neuro-inspired implementations allow developing complex, multilayer, multichip neuromorphic systems and have been used to design sensor chips, such as retinas and cochlea, processing chips, e.g. filters, and learning chips. Furthermore, Cellular Automata is a bio-inspired processing model for problem solving. This approach divides the processing synchronous cells which change their states at the same time in order to get the solution.Ministerio de Educación y Ciencia TEC2006-11730-C03-02Ministerio de Ciencia e Innovación TEC2009-10639-C04-02Junta de Andalucía P06-TIC-0141

Frequency Analysis of a 64x64 Pixel Retinomorphic System with AER Output to Estimate the Limits to Apply onto Specific Mechanical Environment

The rods and cones of a human retina are constantly sensing and transmitting the light in the form of spikes to the cortex of the brain in order to reproduce an image in the brain. Delbruck’s lab has designed and manufactured several generations of spike based image sensors that mimic the human retina. In this paper we present an exhaustive timing analysis of the Address-Event- Representation (AER) output of a 64x64 pixels silicon retinomorphic system. Two different scenarios are presented in order to achieve the maximum frequency of light changes for a pixel sensor and the maximum frequency of requested directions on the output AER. Results obtained are 100 Hz and 1.66 MHz in each case respectively. We have tested the upper spin limit and found it to be approximately 6000rpm (revolutions per minute) and in some cases with high light contrast lost events do not exist.Ministerio de Ciencia e Innovación TEC2009-10639- C04-0

Methods for autonomous wristband placement with a search-and-rescue aerial manipulator

A new robotic system for Search And Rescue (SAR) operations based on the automatic wristband placement on the victims’ arm, which may provide identification, beaconing and remote sensor readings for continuous health monitoring. This paper focuses on the development of the automatic target localization and the device placement using an unmanned aerial manipulator. The automatic wrist detection and localization system uses an RGB-D camera and a convolutional neural network based on the region faster method (Faster R-CNN). A lightweight parallel delta manipulator with a large workspace has been built, and a new design of a wristband in the form of a passive detachable gripper, is presented, which under contact, automatically attaches to the human, while disengages from the manipulator. A new trajectory planning method has been used to minimize the torques caused by the external forces during contact, which cause attitude perturbations. Experiments have been done to evaluate the machine learning method for detection and location, and for the assessment of the performance of the trajectory planning method. The results show how the VGG-16 neural network provides a detection accuracy of 67.99%. Moreover, simulation experiments have been done to show that the new trajectories minimize the perturbations to the aerial platform.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Calibration of WAVE in irrigated maize: fallow vs. cover crops.

Nitrate leaching decreases crop available N and increases water contamination. Replacing fallow by cover crops (CC) is an alternative to reduce nitrate contamination, because it reduces overall drainage and soil mineral N accumulation. A study of the soil N and nitrate leaching was conducted during 5 years in a semi-arid irrigated agricultural area of Central Spain. Three treatments were studied during the intercropping period of maize (Zea mays L.): barley (Hordeum vulgare L.), vetch (Vicia villosa L.), and fallow. Cover crops, sown in October, were killed by glyphosate application in March, allowing direct seeding of maize in April. All treatments were irrigated and fertilised following the same procedure. Soil water content was measured using capacity probes. Soil Nmin accumulation was determined along the soil profile before sowing and after harvesting maize. Soil analysis was conducted at six depths every 0.20m in each plot in samples from 0 to 1.2-m depth. The mechanistic water balance model WAVE was applied in order to calculate drainage and plant growth of the different treatments, and apply them to the N balance. We evaluated the water balance of this model using the daily soil water content measurements of this field trial. A new Matlab version of the model was evaluated as well. In this new version improvements were made in the solute transport module and crop module. In addition, this new version is more compatible with external modules for data processing, inverse calibration and uncertainty analysis than the previous Fortran version. The model showed that drainage during the irrigated period was minimized in all treatments, because irrigation water was adjusted to crop needs, leading to nitrate accumulation on the upper layers after maize harvest. Then, during the intercrop period, most of the nitrate leaching occurred. Cover crops usually led to a shorter drainage period, lower drainage water amount and lower nitrate leaching than the treatment with fallow. These effects resulted in larger nitrate accumulation in the upper layers of the soil after CC treatments

Structural instability of vortices in Bose-Einstein condensates

In this paper we study a gaseous Bose-Einstein condensate (BEC) and show that: (i) A minimum value of the interaction is needed for the existence of stable persistent currents. (ii) Vorticity is not a fundamental invariant of the system, as there exists a conservative mechanism which can destroy a vortex and change its sign. (iii) This mechanism is suppressed by strong interactions.Comment: 4 pages with 3 figures. Submitted to Phys. Rev. Let

Predictive model for scanned probe oxidation kinetics

Previous descriptions of scanned probe oxidation kinetics involved implicit assumptions that one-dimensional, steady-state models apply for arbitrary values of applied voltage and pulse duration. These assumptions have led to inconsistent interpretations regarding the fundamental processes that contribute to control of oxide growth rate. We propose a model that includes a temporal crossover of the system from transient to steady-state growth and a spatial crossover from predominantly vertical to coupled lateral growth. The model provides an excellent fit of available experimental data